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Public Health Service), computerized stereology applications continue to minimize or eliminate the need for user-based data collection. With strong support from the SBIR program of the NIH (U.S. Referees are urged to insist on unbiased counts when is not adequate.”įinally, collaborations between stereologists and computer engineers led to highly efficient computerized stereology systems that dramatically increased the speed of data collection over non-computerized methods. We expect that any papers that use simple profile counts, or assumption-based correction factors, will produce adequate justification for these methods. “Stereologically based unbiased estimates are always preferable for establishing absolute counts or densities of structures in tissue sections.
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For example, the following “Letter from the Editor” appeared in the Journal of Comparative Neurology : Second, editors of prestigious journals and grant reviewers began specifying their preferences for design-based stereology methods over assumption- and model-based (biased) approaches. These courses taught scientists Ewald Weibel’s “Do More, Less Well” concept of increasing efficiency by sampling at the greatest sources of variation.
R WEIBOL EWALD STEREOLOGY PROFESSIONAL
Professional scientists with strong stereology training established annual workshops and courses on applications of unbiased stereology to biological systems. Several events contributed to a large spike in stereology-related papers in the scientific literature. The ISS continues today with distinction as the largest multidisciplinary collaboration of international scientists with a non-war purpose in human history The following year the International Society for Stereology (ISS) convened for its first congress in Vienna, Austria. The purpose of this gathering was to share and discuss approaches for quantifying 3-D objects based on their appearance on 2-D sections.Īfter a brief notice about the stereology meeting appeared in Science, Elias received phone calls and mail from scientists in academia, government agencies, and private industry requesting information about the next stereology meeting. Stereology as a scientific discipline did not exist until German-born histology Professor Hans Elias organized the first meeting in 1961.įor this small conference, Elias brought scientists from the fields of biology, geology, engineering, and materials sciences to the Feldberg, a mountaintop retreat in the Black Forest of Germany. Stereology, derived from the Greek stereos, is a coined term that refers to the analysis of objects in 3-D. For centuries dating back to ancient Greeks and Egyptian civilizations, humans have sought methods to quantify 3-D objects.